Help me to design a progression map for science from ages 4 to 16 detailing the knowledge that we would expect learners of ages 4, 7, 11,13 and 16 to know about biology.

Give detailed examples of the specific knowledge at each age.

When you write this, call age 4, Progression Step 1, age 7, Progression Step 2, age 11, Progression Step 3, age 13, Progression Step 4, age 16, Progression Step 5.

Then remove all references to the age of learners, just leave Progression Steps.

Progression Step 3
At this stage, learners are expected to deepen their understanding of biology and explore more advanced concepts such as genetics and ecosystems. They are also expected to understand the impact of human activity on the environment. Some examples of specific knowledge at this progression step include:

* Understanding the basic principles of genetics, such as dominant and recessive traits, and the role of DNA in inheritance.
* Identifying and describing different ecosystems and the organisms that inhabit them, and understanding the interactions between living and non-living components of an ecosystem.
* Recognizing the importance of biodiversity and the impact of human activity on the environment, such as deforestation, pollution, and the conservation of endangered species.
* Understanding the basic principles of adaptation and evolution, and how these processes contribute to the diversity of life on Earth.
* Identifying and describing the basic functions of major organs and organ systems, including the heart, lungs, and brain.
* Understanding the basic principles of nutrition and digestion, including the roles of enzymes and the digestive system in breaking down food.
* Identifying and describing the basic functions of the immune system, including the body's response to pathogens and the role of vaccines in preventing disease.
* Understanding the basic principles of energy flow and nutrient cycling in ecosystems, including the roles of producers, consumers, and decomposers.
* Identifying and describing the basic functions of the endocrine system, including the role of hormones in regulating body processes.
* Understanding the basic principles of biotechnology, including genetic engineering and cloning.

| "Student-centered" | "Differentiated Instruction" | "Active learning" | "Engagement" | "21st Century Skills" |
| "Project-based learning" | "Flipped classroom" | "Personalized learning" | "Assessment for Learning" | "Collaboration" |
| "Inquiry-based learning" | "Authentic Assessment" | "Critical thinking" | "Blended learning" | "Technology Integration" |
| "Metacognition" | "Scaffolding" | "Student voice and choice" | "Culturally responsive teaching" | "Formative assessment" |
| "Gamification" | "Social and emotional learning" | "Universal Design for Learning" | "Higher order thinking" | "Teacher efficacy" |

Write some code in Python to search through the first 1000000 numbers and display those that meet all the following criteria:

1. Is a palindrome
2. Is a Harshad number
3. Is a cyclops number

When you write the code, use as many techniques as you can to make the code as quick as possible.  Please explain how the code works

def is_palindrome(N_STR):
   return N_STR == N_STR[::-1]

def is_cyclops(N_STR):
   if len(N_STR) % 2 == 0:
       return False
   middle = len(N_STR) // 2
   return N_STR[middle] == '0'

def is_harshad(n):
   digit_sum = 0
   nsum = n
   while nsum > 0:
       digit_sum += nsum % 10
       nsum //= 10
   return n % digit_sum == 0

for n in range(1, 1000000):
   if n % 10 == 0:
       continue  # no need to check multiples of 10
   N_STR = str(n)
   if is_palindrome(N_STR) and is_cyclops(N_STR) and is_harshad(n):
       print(n)

This code searches through the integers from 1 to 999999 and checks if they are palindrome, cyclops, and Harshad numbers. Here is how each function works:

is_palindrome(N_STR): This function checks whether a given string N_STR is a palindrome. It returns True if the string is the same forwards and backwards (i.e., a palindrome), and False otherwise. This is achieved by checking if N_STR is equal to its reverse, which is done by slicing the string with [::-1].

is_cyclops(N_STR): This function checks if a given string N_STR is a cyclops number. A cyclops number is a positive odd number that has exactly one zero in the middle. The function first checks if N_STR has an odd number of digits, and if it does not, returns False. If N_STR has an odd number of digits, it finds the middle index and checks if the character at that index is '0'.

is_harshad(n): This function checks whether a given integer n is a Harshad number. A Harshad number is a positive integer that is divisible by the sum of its digits. The function calculates the sum of the digits of n using a loop and stores it in digit_sum. It then returns True if n is divisible by digit_sum, and False otherwise.

The code then iterates through the integers from 1 to 999999, skipping multiples of 10 as they are not palindromic. For each integer, it converts it to a string N_STR and checks if it is a palindrome, a cyclops number, and a Harshad number using the three functions. If all three checks pass, it prints the integer.

def is_harshad(n):
  digit_sum = 0
  nsum = n
  while nsum > 0:
      digit_sum += nsum % 10
      nsum //= 10
  return n % digit_sum == 0